Hi Debbie,
Does the file have an .xlsx extension? if yes, are you able to see any sheets tabs below?
Are you able to create blank sheets at all?
If you are not able to see any sheets and cannot create new ones, I am suspecting the file may be corrupt or may not even be a spreadsheet.
Trying repairing the File:
In Excel, Go to File -> Open, browse to this file in the thumb drive, click the dropdown arrow next to Open, and choose Open and Repair.